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Cardiac Biomechanics Lab »  People »  Principal Investigators »  Julius M. Guccione, Jr., Ph.D.

Julius M. Guccione, Jr., Ph.D.

Professor of Surgery
Division of Adult Cardiothoracic Surgery
Co-Director, Cardiac Biomechanics Lab
Core Member, UC Berkeley & UCSF Graduate Program in Bioengineering

Contact Information

Box 0118
UC Hall Room U-158
415.750.2181 (Fax)
415.680.6285 (Cell/Mobile)
julius.guccione@ucsf.edu
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Tulane University B.S. Biomedical Engineering, 1985

UCSD, M.S. Engineering Sciences (Bioengineering), 1987

UCSD, Ph.D. Engineering Sciences (Bioengineering), 1990

  • Postdoctoral Fellow, Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 1990-1993
  • Member, UCB/UCSF Graduate Bioengineering Program

Julius M. Guccione, Jr., Ph.D. is Professor of Surgery, Surgery/Division of Adult Cardiothoracic Surgery at UCSF. He specializes in the realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. Dr. Guccione graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

The American Institute for Medical and Biological Engineering (AIMBE) inducted Dr. Guccione, Jr., Ph.D.,  to its College of Fellows in March 2019. Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer.

The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to "engineering and medicine research, practice, or education" and to "the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education." 

Dr. Guccione was nominated, reviewed, and elected by peers and members of the College of Fellows for "outstanding contributions to the development, validation and dissemination of a unified foundation for cardiovascular in silico medicine."

  Award  
  Confired By    
  Date    
  • AIMBE Fellow
  • American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
  • 2019
  • Richard Skalak Best Paper Award of the ASME Bioengineering Division
  • 1999
  • Individual National Research Service Award of the NIH
  • 1991 - 1993
  • Institutional National Research Service Award
  • Johns Hopkins University, Baltimore, MD
  • 1990 - 1991
  • Institutional National Research Service Award
  • University of California, San Diego, CA
  • 1985 - 1990
  • Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. Recently, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

    Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

    See also: The 3D Living Heart Project Overview

    Data provided by UCSF Profiles, powered by CTSI
    • Optimization of Transcatheter Treatment for Severe Tricuspid Regurgitation
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      Mar 2020
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      Feb 2024
      Principal Investigator
    • Model-Guided Vagus Nerve Stimulation for Heart Failure Therapy
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      Aug 2020
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      Jul 2022
    • Cost Effective Drug Screening
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      Mar 2020
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      Feb 2021
      Principal Investigator
    • Real-Time Virtual Assessment of MitraClip Placement
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      Apr 2019
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      Mar 2020
      Consultant
    • Multi-Scale Laws of Myocardial Growth and Remodeling
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      Jul 2014
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      Jun 2019
      Principal Investigator
    • Quantitative analysis of left ventriculoplasty: CHF
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      Apr 2000
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      Apr 2018
      Co-Investigator
    • Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure
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      Sep 2013
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      Jun 2017
      Principal Investigator
    • VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY
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      Apr 2006
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      Aug 2016
      Principal Investigator
    • Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration
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      Aug 2009
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      Jul 2011
      Principal Investigator
    • REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
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      Sep 1997
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      Aug 2001
      Principal Investigator
    • Regional Mechanical Properties of Intact Ventricular Muscle
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      Aug 1994
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      Jul 1997
      Principal Investigator
    • VENTRICULAR MUSCLE MECHANICS UNDER PHYSIOLOGICAL LOADING
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      Dec 1991
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      Jan 0001
      Principal Investigator
    MOST RECENT PUBLICATIONS FROM A TOTAL OF 158
    Data provided by UCSF Profiles, powered by CTSI
    1. Shavik SM, Wall S, Sundnes J, Guccione JM, Sengupta P, Solomon SD, Burkhoff D, Lee LC. Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res. 2021 Apr 29. View in PubMed
    2. Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB. Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain. J Mech Behav Biomed Mater. 2021 Mar 27; 119:104431. View in PubMed
    3. Wisneski AD, Cutugno S, Stroh A, Pasta S, Yao J, Mahadevan VS, Guccione JM. From clinical imaging to patient-specific computational model: rapid adaptation of the Living Heart Human Model to a case of aortic stenosis. Functional Imaging and Modeling of the Heart. 2021. View in PubMed
    4. Precision medicine in human heart modeling : Perspectives, challenges, and opportunities. Biomech Model Mechanobiol. 2021 Feb 12. View in PubMed
    5. Dabiri Y, Van der Velden A, Sack KL, Choy JS, Guccione JM, Kassab GS. Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics. Sci Rep. 2020 Dec 18; 10(1):22298. View in PubMed
    6. View All Publications

     

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