University of California San Francisco

Cardiac Biomechanics Research Lab - Homepage

Lab Co-Directors

Mark Ratcliffe, M.D.

Mark Ratcliffe, MD

Professor of Surgery
Division of Adult Cardiothoracic Surgery

Elaine Tseng, M.D., FACS

Elaine Tseng, MD

Professor of Surgery
Division of Adult Cardiothoracic Surgery

Liang Ge, PhD

Liang Ge, PhD

Assistant Professor of Surgery
Division of Adult Cardiothoracic Surgery

Welcome to the Cardiac Biomechanics Lab

The Cardiac Biomechanics Laboratory is a multi-disciplinary research collaborative that investigates cardiovascular disease and intervention with state-of-the art computational techniques. The heart and cardiovascular system is one of the most complex, dynamic systems in the human body. Derangements of the left ventricle, mitral and aortic valves, and the ascending aorta impart devasting consequences on patients’ lives.

With the advancement of radiographic image processing and through experimental studies of ventricular and aortic tissue, we can construct high fidelity models of the left ventricle, aortic root, and ascending aorta offering an unprecedented degree of data. The techniques of finite element modeling, computational fluid dynamics, fluid structure interaction, and tissue biaxial testing are some of the methods our investigations employ.

Our group aims to usher in the future of cardiovascular disease research with integration of data from patient-specific models scalable to larger datasets representative of the population. We host lab space for computational and experimental studies at the San Francisco Veterans Affairs Medical Center, and collaborations exist with faculty and labs at a number of institutions around the country. Drawing from the expertise of tissue biomechanics professors, cardiothoracic surgeons and interventionalists, our group is uniquely positioned to tackle some of the most challenging issues in cardiovascular disease today.

Research
Cardiac Biomechanics Research lab hp banner
Ascending Thoracic Aortic Aneurysm and Dissection Approximately 30,000 people in the US are diagnosed with thoracic aortic aneurysms ...
Bi-axial Stretching Apparatus We utilize a custom made biaxial stretcher to determine the biaxial stiffness of certain biologic ...
Borderzone Dysfunction It has been known since the mid 1980s that systolic performance (systolic shortening and wall thickening) ...
Computational Simulation of Transcatheter Aortic Valve Replacement (TAVR) Aortic stenosis (AS) is the most common heart valve disease ...

Recent Publications

  1. Temporal Evolution of Ascending Aortic Aneurysm Wall Stress Predicts All-Cause Mortality.
    2024 | View in PubMed
  2. Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.
    2024 | View in PubMed
  3. A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation
    2023 | View in PubMed
  4. Imaging and Computational Modeling of Tricuspid Regurgitation and Repair
    2023 | View in PubMed
  5. On the Role of Ionic Model in the Signature of Cardiac Arrhythmias for Healthy and Diseased Hearts
    2023 | View in PubMed

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